In a bowl, combine the buttermilk, paprika, garlic powder, onion powder, cayenne pepper, salt, and pepper. Submerge the chicken breasts in the marinade, cover, and refrigerate for at least 1 hour (or up to overnight for maximum flavor).
In a small bowl, mix together the softened butter and honey until well combined. Set aside.
In another bowl, place the flour and season with salt, paprika, garlic powder, onion powder, and cayenne pepper. Remove the chicken from the buttermilk marinade, allowing excess to drip off, then dredge each piece thoroughly in the seasoned flour.
Heat about 1 inch of vegetable oil in a large skillet over medium-high heat. Once the oil reaches 350°F (175°C), carefully add the coated chicken to the pan. Fry for about 6-8 minutes per side, or until golden brown and cooked through (internal temperature should reach 165°F or 74°C). Remove and place on a paper towel-lined plate to drain excess oil.
Lightly toast the brioche buns on a pan or griddle. Spread a generous amount of the honey butter on the bottom half of each bun. Place a fried chicken piece atop the honey butter, then top with coleslaw and pickles. Finally, add the top half of the bun.
Enjoy your delicious honey butter fried chicken sandwiches while they’re warm!